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Once freed, vitamin B12 initially binds to haptocorrin (R-protein) in the stomach before being transferred to intrinsic factor, a glycoprotein secreted by parietal cells in the stomach lining

No direct pharmacological link exists between GLP-1/GIP medicines and B12 deficiency, but concurrent metformin use (common in diabetes) is established to reduce B12 absorption

The lower bridge introduces glucagon gradually

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Speaking to a UK Healthcare Professional About These Treatments Patients interested in these treatments should speak to their GP or an obesity medicine specialist, who can assess eligibility for licensed therapies or clinical trials via NHS Tier 3 weight management services