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The interaction between NO and O2 releases peroxynitrite anion (ONOO), affecting cell proliferation, leading to the degradation of connective tissue and joint tissue deterioration (Fig

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doi: 10.3390/bios12100879 318 TangBZengWSongLLWangHMQuLQLoHHet al

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8.5 Cell-free strategies In recent years, researchers have discovered that extracellular vesicles (EVs) secreted by stem cells, such as exosomes and microvesicles, possess immunomodulatory functions similar to stem cells (Yu et al., 2014)