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In the presence of IL-4 and Il-13, the B cell undergoes class switching to produce IgE (43), which can induce the release of pro-inflammatory cytokines and the expression of HLA-DR

Nevertheless, the effects of MAPK/ERK depend on the intensity of the activation of this cascade, and different outcomes are possible ( in vivo (Zhang et al., 2022)

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[DOI] [PubMed] [Google Scholar] 271.Zhang Y.T., Li Y.L., He Y.W., Hu W.J., Zhang Y., Wang X.R., Tang H.R

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