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Appointed the drug as an independent agent or as part of complex therapy

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MOTS-c, a mitochondrial-derived peptide, has been studied for its role in AMPK-dependent metabolic regulation (Lee et al., 2015, Cell Metabolism)

By 1988, Upjohn had reformulated it as a topical solution and earned FDA approval for androgenetic alopecia.1 The mechanism is still not fully understood, but the dominant theory is that minoxidil functions as a potassium channel opener

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