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Material and Methods A systematic review of the literature was carried out according to PRISMA guidelines11 for the conduct of meta-analysis of intervention trials

It examines its combined effects with hydration strategies on endurance performance in swimmers, comparing it against a standard single-dose method: a standard protocol (2 g of LC taken 60 min before exercise) and an experimental protocol (1 g of LC taken 90 and 60 min before exercise)

This collaborative approach helps ensure appropriate individualization of treatment while minimizing the risk of adverse effects

The established Observed Safe Level (OSL) for chronic, long-term supplementation is generally recognized as 2,000 mg per day, though higher doses have been used safely in monitored trials

Enzyme Res