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This study offers a highly valuable proteomic resource for AV associated with IR and proposes a mechanistic hypothesis, supported by existing literature, that insulin exacerbates acne by regulating lipid metabolism and inflammatory pathways with C4BPA potentially acting as a central mediator in this process

Simova et al., 2002)

Moreover, the solubility of ivermectin in HBSS-AB was lower due to medium components like salts, sugar and antibiotics, which reduced the maximum soluble concentration to 625 nM