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Because NAD+ levels naturally decline with age, approaches aimed at maintaining or restoring NAD+ have become a major focus in aging research

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doi: 10.1093/aob/mcz184 44 DuF.HuZ.QinL.ZhangC.WangZ.ShiY.et al

One study involving over 300 twins speaks to the importance of the legs in particular: greater strength and power in the legs in particular was associated with an increased brain volume 10 years later and less brain aging in over 300 twins 3 Kicking Back Cognitive Ageing: Leg Power Predicts Cognitive Ageing after Ten Years in Older Female Twins Steves et al

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