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Dihexa (PNB-0408) is a synthetically derived Angiotensin IV analog that is blood-brain barrier permeable, stable, and orally bioavailable [1]

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As a result, the k cat / K m of K240A toward both tyrosine and DOPA was also decreased, indicating that mutation of lysine-240 to alanine might affect the affinity of enzyme and substrates by altering the conformation of adjacent amino acids, particularly H241

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Therefore, careful examination of patients to rule out dural sac tears is imperative before proceeding with PEID