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The depletion of brain glutathione has been linked to various neurological conditions, emphasizing the importance of maintaining adequate levels of this antioxidant for neurological health 2

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and subsequently to activate the thiol group of GSH, enabling the nucleophilic attack upon the substrate

Duchenne muscle dystrophy (DMD) is a genetic muscle disease manifesting clinically during childhood

[22] The NIH "Roadmap Epigenomics Project", which ran from 2008 to 2017, uses the following definition: "For purposes of this program, epigenetics refers to both heritable changes in gene activity and expression (in the progeny of cells or of individuals) and also stable, long-term alterations in the transcriptional potential of a cell that are not necessarily heritable." [23] In 2008, a consensus definition of the epigenetic trait, a "stably heritable phenotype resulting from changes in a chromosome without alterations in the DNA sequence," was made at a Cold Spring Harbor meeting