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The cultures were maintained in 35-mm polystyrene culture dishes at 37C within a humidified atmosphere containing 5% CO to mimic physiological conditions [1]

The peptide's antioxidant mechanism operates through activation of the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway, a master regulator of cellular antioxidant responses

These cytotoxic agents, commonly referred to as chemotherapeutic drugs, can act in several ways, such as interfering with DNA replication, disrupting cell division, or triggering apoptosis (programmed cell death) [56]

And it delivers copper to enzymes called lysyl oxidase and lysyl hydroxylase, which are responsible for cross-linking collagen fibers into strong, stable structures

Analytical testing

challenged rhesus macaques with SARS-CoV nine weeks post-immunization with an inactivated vaccine, when neutralizing antibody titres had waned below protective levels 68