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Toxic Polyneuropathy desmoglein-3 (999 aa, ~108 kda) is encoded by the human dsg3 gene

(B) Oligodendrocyte cell death caused by activated astrocytes and microglia in response to oligodendrocyte damage, which we term toxic innate immunity and (C) oligodendrocyte cell death caused by astrocytes and microglia following a direct effect of cuprizone on these cells, which we term primary immunocytopathy

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Subcutaneous injection bypasses first-pass hepatic metabolism, delivering more active peptide to target tissues

doi:10.1172/JCI93557 Hussein, A