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Therefore, rapid scavenging of H 2 O 2 , via ascorbate peroxidase, is extremely important for a potent antioxidant system (Asada, 2 O 2 in the absence of APXs without significant effects on the redox balance of ASC/DHA/ or GSH/GSSG and the coupling between ASC and GSH-related redox systems was weak (Polle, 2001)

Next, Cys58 nucleophilically attacks the sulfide of Cys58, releasing a GS- anion, which picks up a solvent proton and is released from the enzyme, forming the second GSH

P., Tezenas-du, Montcel S., and Deray, G

Food Res Int 140:110064

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328 Elevated IDO1 activity in GBM leads to tryptophan depletion and increased kynurenine production, which leads to GCN activation, PD-1/PD-L1 upregulation, AHR activation, and increased kynurenine metabolite production