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( A ) Immunoblot analysis to detect HJURP with an anti-HJURP antibody in Tet-based HJURP conditional knockout (cKO) cells expressing EGFP-HJURP (WT) or EGFP-HJURP 2E (2E) at the indicated time points after Tet addition

Male germ cells that lack Dicer exhibit aberrant sperm shape, reduced motility, and a reduced capacity for fertilization

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It downregulated Acsl4 and ferroptosis in the salivary glands of NOD/LtJ mice

10.1038/nature01960 37 HuB.LiJ.GongD.DaiY.WangP.WanL.et al (2022)

4.3 Autoimmune hepatitis (AIH) AIH is a progressive and chronic inflammatory liver disease possibly induced by the reciprocity of an inducement and environmental factors in a genetically vulnerable individual, affecting mainly females ( 4.4 Hemochromatosis HH is a hereditary disease manifesting excessive iron deposits in the tissues caused by autosomal recessive disorder ( 4.5 NAFLD/nonalcoholic steatohepatitis (NASH) NAFLD and its advanced stage, NASH, have attracted much attention due to their expanding influence on global health (Yang et al., 2020