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Hypoxia leads to the increase of erythropoietin (EPO) and serum TF, which eventually leads to abnormal iron metabolism, thus promoting ferroptosis

DMPS has shown effective mobilization of mercury from kidney and reduced its biological half life [191]

Glossary DFU Diabetic foot ulcer CeO 2 NPs Cerium oxide nanoparticles ROS Reactive oxygen species ECM Extracellular matrix AGEs Advanced glycation end-products MSN@Met-CeO 2 Mesoporous Silica Nanoparticle loaded with Metformin and Cerium Dioxide DRP1 Dynamin-related protein one PVs Polymer vesicles PLGA Poly(lactic-co-glycolic acid) SiO 2 Silicon dioxide PEG Polyethylene glycol GelMA Gelatin methacryloyl PEGDA Poly(ethylene glycol) diacrylate Tau Taurine CTH@MN CeO 2 @Tau hydrogel microneedle patch Exos Exosomes HIF-1 Hypoxia-inducible factor 1-alpha SOD Superoxide dismutase CAT Catalase GPx Glutathione peroxidase CS-TA@CeO 2 Chitosantannic acidcerium oxide cryogel CIP-Ceria-PVs Ciprofloxacin-loaded cerium-decorated polymer vesicles pH Potential of hydrogen ML Machine learning NPs Nanoparticles SBQCC/CNPs Sodium alginate-benzeneboronic acid/Quaternized chitosan-catechol with Cerium oxide nanoparticles MSC Mesenchymal stem cell EPCs Endothelial progenitor cells ECFCs Endothelial colony-forming cells References 1 AfonsoA

doi: 10.1038/nrm.2017.36 45 RaduPZurzuMPaicVBratucuMGarofilDTigoraAet al

Similar content being viewed by others Introduction Cancer, one of modern medicines most complex and challenging diseases, significantly affects global health systems

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