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Efficacy of NNMT inhibitor 5-amino-1MQ in diet-induced obese (DIO) mice 17-week old, male DIO C57Bl/6 mice that have been fed high-fat diet (HFD) for 11 weeks (starting at week 6) were purchased from Jackson Labs (Jackson Laboratory

Within the cell, estrogens bind to their membrane-bound receptors, activate the MAP kinase-NFB pathway, and increase transcription of antioxidant enzymes, especially GPx and superoxide dismutase (SOD) 2 (27)

Other studies in the same era found that improvement did not reach clinically significant differences from placebo

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