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AR is supported by a grant from IISPV through the project 2019/IISPV/05 (Boosting Young Talent), by GeSIDA through the III Premio para Jovenes Investigadores 2019 and by the Instituto de Salud Carlos III (ISCIII) under grant agreement CP19/00146 through the Miguel Servet Program

In the early stage of tumor colonization or growth, activated immune cells contribute to a tumor-suppressive inflammatory microenvironment that hinders tumor development, whereas long-term persistent antigenic stimulation, the activation of immunosuppressive cells and metabolic stress prompt the tumor to escape from the surveillance of the immune system and continue to grow, which is known as immune escape of the tumor (70,71)

It is at this time that our youthful self-consciousness wears off, communication becomes more comfortable, and greater creativity is embraced

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2.3.4 Resveratrol Resveratrol, a stilbene from Vitis vinifera, downregulates NF-B and STAT3 pathways, suppressing Th17 differentiation and keratinocyte proliferation [48, 49]

official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery 42 (3), 557563