low glutathione and covid Effects of oxidative stress on viral infections: an overview How Keeping Glutathione Levels Up

Particularly in different pathophysiological scenarios, mitophagy has been confirmed to exert both protective and detrimental effects, and the underlying mechanisms of this bidirectional regulatory effect have not yet been fully elucidated

Nitric oxide upregulates expression of DNA-PKcs to protect cells from DNA-damaging anti-tumour agents

A peculiar fact on neurodegenerative disorders is that they are normally characterized by an increased ROS production (Loef et al., 2011) and the decline of BBB and BCB (Sengillo et al., 2013) and human studies (Skillbck et al., 2017) indicate the vulnerability of the NVU in Alzheimers disease, the most common neurodegenerative disease (Muoio et al., 2014), and both protective and trophic functions of the neural barrier seem to be impaired (Zenaro et al., 2017)

de Koning, H

Choi S, Youn J, Kim K, Joo da H, Shin S, Lee J, Lee HK, An IS, Kwon S, Youn HJ, et al

Evidence about the role of mtROS has led to the development of MATs for therapeutic intervention in several diseases, including HTN -Figure 2 (Jiang et al., 2020