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Liu X, Wang Q, Yang G, Marando C, Koblish HK, Hall LM, et al

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Furthermore, comorbidities such as hypertension (56.6%), obesity (41.7%), and diabetes (33.8%) are frequently linked to OxS and chronic inflammation in hospitalized COVID-19 patients 596

By contrast, in CD8 T cells, deficiency of these NF-B early signaling intermediates raises the threshold of TCR signaling required for proliferation, resulting in impaired CD8 T cell proliferation even with strong agonistic TCR stimulation (78)

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