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2 Assay principle Cells expressing G protein-gated inwardly rectifying potassium channels (GIRK) were loaded with thallium as a surrogate for potassium and Thallos, a thallium-sensitive dye (Figure 1)

If so, dHTC1 may exploit a weak native interaction between ENL and CRBN to form a stable ternary complex, which is a common feature of diverse molecular glues 103

1) is distinct among sirtuins due to its ability to remove specific acyl post-translational modifications (PTMs), including succinylation, malonylation, and glutarylation, thereby modulating the function of both mitochondrial and cytoplasmic proteins

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Their ability to enhance gut integrity, support liver detoxification processes, and modulate systemic responses underscores their potential within the context of the gutliverhypothalamus axis