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Although many other panels making clinical recommendations using evidence-based methods are able to require that randomized trials be available to reach strong conclusions, the IOM committee was convened specifically to assess topics that are of immediate concern yet for which data may just be emerging

Yet, the central nervous system, with its relatively diminished glutathione reserves, is particularly susceptible to oxidative challenges [201, 202], potentially leading to ferroptosis

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Of these, eNOS generates nearly half of the circulating NO and is primarily responsible for sustaining vascular tone under baseline conditions

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