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Available at: New England Journal of Medicine+1 Ladenheim EE

[] Specifically, PGC-1 robustly stimulates mitochondrial biogenesis and respiratory function by inducing the expression of the NRF1 and NRF2

In ALS patient with longer survival, peripheral IGF-1 concentrations were increased by 58% compared to controls 18 , suggesting that higher IGF-1 concentrations may be associated with favorable survival