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Moreover, the lipid droplet forming potential of cancers has been associated with increased survival in hypoxic environments such as the light zone of germinal centres 3,82,83

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5 As humans migrated, early dogs may have followed, and by 11,000 years ago, at least five genetically diverse ancient dog breeds could be found in the human-settled regions of Northern Europe, Central and Southeast Asia, and the Americas

Finally, several drugs, especially VPA but also anti-HIV nucleoside analogues, pivalic acid-containing antibiotics and some chemotherapy agents (e.g