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Pharmacotherapy, 42(9), 659-667

Ligand valency affects transcytosis, recycling and intracellular trafficking mediated by the neonatal Fc receptor

Interestingly, AQP4 knockout mice produced seizures for a longer period and slowed K + kinetics, and the seizure latency was increased when the hippocampal circuit was electrically stimulated (Binder et al., 2006)