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This compares favorably to the safety profile of PDE5 inhibitors where side effects such as headache and flushing occur in over 25% of patients, a rate 2 to 3 times higher than with placebo [46, 47]

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Samson et al, 2015) was used to assess locomotion and anxiety-like behaviour in an exposed environment

more fibrotic tissues infiltrate inside the nerve fascicles (more blue component)

10 DOACs also have comparable or better safety profiles, with no difference in major bleeding and a lower risk of intracranial bleeding