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While translational gaps persist, particularly in dosing, timing, and patient stratification, emerging strategies including mitochondria-targeted antioxidants, nanotherapeutics, and biomarker-guided interventions hold promise for restoring redox homeostasis and improving clinical outcomes

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However it should be noted that the biological activities and therapeutic effects of polyphenols are also potentially mediated by their metabolites formed in the gut, liver, or gut microbiota, therefore demonstrating the complexity of polyphenols in this context [589,590]

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Athletes should be aware that: Ipamorelin can trigger a positive drug test Testing agencies may screen for elevated GH/IGF-1 levels or peptide metabolites For those in competitive sports, even a short cycle of Ipamorelin could lead to disqualification or suspension