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Metabolite intermediates or other specific macromolecules leverage porins and outer membrane transporters (TOM) to cross the mitochondrial membrane into the inner mitochondrial space (IMS) or mitochondrial matrix, regulating the TCA cycle and oxidative respiratory chain [20]

After final plating, the hepatocytes were maintained in culture for 24 hr prior to use

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Immunotherapies targeting -syn aggregates offer new hope for disease-modifying treatment in PD

Hhex flox/flox and four WT littermates were analyzed by bulk RNA sequencing

Similarly, Arg catabolism is coupled with the urea cycle to produce bioactive metabolites such as polyamines to support T cell proliferation and differentiation 10,11,12