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Functional assays identified hepatocyte growth factor (HGF) and its primary receptor cMet as critical in MSC-stimulated recovery in EAE, neural cell development and remyelination

Moreover, in HG-stimulated cells, downregulation of the antioxidant genes superoxide dismutase 2 (SOD2) (Fig

When these receptors activate, fat cells release stored lipids for energy use

Moreover, ablation of these genes leads to the complete absence of hypaxial muscles (diaphragm, limbs, tongue), reflecting that HGF-MET have a pivotal role in proliferation and motility of these muscle progenitors (Birchmeier and Gherardi, 1998)

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