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TsalamandrisSAntonopoulosASOikonomouEPapamikroulisG-AVogiatziGPapaioannouSet alThe role of inflammation in diabetes: current concepts and future perspectives

Experimental neurology 215 , 228235, (2009)

These reactive oxygen/nitrogen species (RONS), namely, hydroxyl, superoxide anion, nitric oxide, and nitrosyl anion, are highly reactive molecules due to their unpaired valence electrons [7]

Aerobic cells possess a proficient antioxidant defense mechanism that serves to counteract the deleterious impact of reactive oxygen species (ROS) through the maintenance of redox homeostasis (3)

Preclinical studies show no significant toxicity at therapeutic doses, with treated animals displaying no adverse behavioral changes or organ dysfunction

(c) expression of Hif 2 and of the NF-B p65 active form