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The VCAM-1 signal area was determined in oval regions of interest encompassing the coronal brain section within each image, and images were manually thresholded by a blinded investigator

Results Immediate physiological effects of repeated mild TBI For the first of three repeated surgeries, no differences in weights were found between injury groups ANOVA (sexXinjury) F (1,48) = 0.5856, p=0.4479)

doi: 10.1038/s41392-022-01110-y

10.1021/cr9700181 183 SalazarS.GuerraD.YutronicN.JaraP

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On the other hand, mGluR imaging, particularly for subtypes 5 and 1, has been found effective ( Moreover, 1 H magnetic resonance spectroscopy (MRS) is also a non-invasive method for the assessment of levels of neurometabolites including glutamatergic ones in the brain ( Furthermore, one can indirectly assess the glutamatergic synapsis in the cortex using transcranial magnetic stimulation (TMS) with paired pulse protocol