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Melanoma Tumor Board

Metformin increases chemo-sensitivity via gene downregulation encoding DNA replication proteins in 5-Fu resistant colorectal cancer cells

In cholangiocarcinoma, combined BET degradation and mTOR inhibition synergistically reduce acetylation of PSAT1-associated H3K27, inducing PSAT1 downregulation and subsequent dysfunction of the serine-glycine-one-carbon (SGOC) pathway (114)

Molecular Oncology 2025, 19: 1295-1298

Curcumin and Resveratrol in the Management of Cognitive Disorders: What is the Clinical Evidence

Generally, the NSAIDs-induced sphincter failure may be quite prominent, at least in the range of that induced mechanically by prolonged stretch, after tube insertion into the lower esophageal and/or pyloric sphincter and sphincter failure in esophagitis rats (30-32), surgically by anastomosis and fistulas creation (26, 27, 29), or chemically, by huge potassium-overdose application (28)