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Cysteine 10 is critical for the activity of Ochrobactrum anthropi glutathione transferase and its mutation to alanine causes the preferential binding of glutathione to the H-site

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Clustering of integral membrane proteins of the human erythrocyte membrane stimulates autologous IgG binding, complement deposition, and phagocytosis

This one target, multiple effects or multiple targets synergistically characteristic enables them to simultaneously disrupt the mutually reinforcing relationships among oxidative stress, neuroinflammation, and protein toxicity

Altogether, these results suggest that Auranofin impairs the expression of genes associated with the MES phenotype

Culture supernatants were collected at 36-, 48-, and 72-hours post-transfection