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Another essential component for executing ferroptosis is acyl-CoA synthetase long-chain family member 4 (ACSL4), as it influences the necessary lipid composition in ferroptosis [46]

These findings illustrate that oxysterols, particularly 25-OH, 7OH, and 7KC, can trigger oxidative stress, apoptosis, and inflammation in RPE cells, thereby inducing retinal degeneration

Methods 187, 12

Using biotin-probe profiling, gene knockout/knock-in models, UPLC-MS metabolomics and computational simulations, the researchers demonstrated that: CD36 binds multiple PROTAC molecules (including SIM1-Me, MZ1 and ARV-110) as well as large-molecule drugs such as rapamycin, navitoclax, birinapant, tubacin and doxorubicin, thereby promoting their cellular uptake and pharmacological activity