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O.et al (2009)

The flavonoid glycoside icariin has been shown to increase the expression of Nrf2, HO-1, and GPX4, in cisplatin-treated mouse ovarian tissues and KGN cells, which may contribute to reduced OS and ferroptosis ( In vitro experiments have demonstrated that another natural flavonoid glycoside, rutin, may alleviate oxidative stress induced by ferroptosis in small white follicles of aging laying chickens via the Nrf2/HO-1 pathway (Wu Y