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How Tobacco Affects Your Immune System File:Tobacco diagram.png Wikimedia Commons Tobacco Cessation The University of Texas System How Long Does Nicotine Stay in Your System? Effects Explained Yay. I'm officially off nicotine! :) "How long does nicotine stay in your system? Once you've stopped smoking, it will take nicotine around 72 hours to leave your body and the withdrawal Tobacco: The Nicotine Trap Pamphlet
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