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In the case of CBS, the function of the AdoMet-binding regulatory domain appeared less important than the catalytic domain to functional complementation, as variants in this domain were generally more likely to be tolerated in our assay

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Gubbiotti MA, McCutcheon IE, Rao P, Genovese G, Wang L , Tarasov A, Putintsev V, Berlinski A, Stupichev D, Kriukov K, Davitavyan S, Salem B, Sarachakov A, Lebedev D, Hensley M, Bagaev A, Paradiso F, Kushnarev V, Khegai G, Tannir NM, Msaouel P