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The mysteries of capsaicin-sensitive afferents

As mentioned earlier, sperm membranes are rich in PUFAs, which are particularly prone to oxidation by ROS

The resulting oxidative stress impairs mitochondrial respiration, compromises ETC function, and increases membrane permeability, resulting in reduced ATP production and potential mitochondrial shutdown [97, 98]

5g, middle panels, lanes 2 and 3)

It's biochemically inactive, converting an expensive research compound into sterile water

Adult female mice exposed to the early-life HFHS diet displayed alterations in circulating metabolites belonging to different metabolite classes, including the microbiota-derived metabolites kynurenine, indole-3-carboxaldehyde, hippuric acid, or pantothenic acid, and the host-derived metabolites creatinine, creatine, tryptophan, 15(S)-HETE, lactic acid or the L-amino acids alanine and arginine (Fig