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In the negative control group (Figure 4A), the liver displayed a normal hepatic architecture characterized by well-organized hepatic cords, intact central veins, and uniformly sized hepatocytes with prominent nuclei and eosinophilic cytoplasm

10.1016/j.tips.2018.02.007 Trends Pharmacol

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The tumor suppressor OTUD1 can bind to and promote the deubiquitination modification of iron response element binding protein 2 (IREB2), the main regulatory factor of iron metabolism