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10.1007/s00253-013-4884-z Appl

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Based on the important role of glutamine in tumorigenesis and progression, it may be a promising direction of targeting its metabolic process to develop new clinical therapies

When extracellular Cu 2+ entered the mitochondria, FDX1 reduced Cu 2+ to Cu + , leading to oligomerization of DLAT protein, a decrease in the expression of Fe-S cluster proteins, and an increase in the level of toxic stress protein in the heat shock protein family A (HSP70), thereby inducing protein toxicity stress and cell death [6]