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GLS1 is the main isotype expressed in cancer cells and has been shown to be upregulated in a variety of cancers, including breast cancer, lung cancer, cervical cancer, and brain cancer

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Unexpectedly, OA/PA-supplemented HepG2 cells did not show reduced ferroptosis sensitivity, instead cell death sensitivity (Fig

The rapid mortality suggests potential acute effects on other systems (e.g., central nervous or cardiovascular) beyond the hepatocellular iron-deficiency pathway characterized in vitro