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Ca 2+ influx into the mitochondrial matrix via MCU and MICU1 is required for oxidative metabolism of glucose and ATP generation in INS1 cells and rat islets (Wiederkehr et al., 2011

That difference becomes more noticeable with larger quantities

The authors thank Nicole Paczia and Peter Claus for performing the HPLC-MS measurements and Enrico Orsi for critical reading of the manuscript and helpful suggestions

Although their mechanisms are multifaceted, emerging interest has focused on KP modulation as one potential contributor

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