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Faust HJ, Cheng T-Y, Korsunsky I, Watts GFM, Gal-Oz ST, Trim WV, Kongthong S, Jonsson AH, Simmons DP, Zhang F, Padera R, Chubinskaya S, Albrecht J, Anolik JH, Apruzzese W, Barnas JL, Bathon JM, Ben-Artzi A, Boyce BF, Boyle DL, Bridges SL, Bykerk VP, Campbell D, Ceponis A, Chicoine A, Curtis M, Deane KD, DiCarlo E, Donlin LT, Dunn P, Filer A, Carr H, Firestein GS, Forbess L, Geraldino-Pardilla L, Goodman SM, Gravallese EM, Rao D, Gregersen PK, Guthridge JM, Gutierrez-Arcelus M, Holers VM, Horowitz D, Hughes LB, Ivashkiv LB, Ishigaki K, James JA, Kang JB, Keras G, Lakhanpal A, Lederer JA, Lewis MJ, Li Y, Liao K, Mandelin AM, Mantel I, Marks KE, Maybury M, McDavid A, McGeachy MJ, Mears JR, Meednu N, Millard N, Moreland L, Nayar S, Nerviani A, Orange DE, Perlman H, Pitzalis C, Rangel-Moreno J, Raza K, Reshef Y, Ritchlin C, Rivellese F, Robinson WH, Rumker L, Sahbudin I, Sakaue S, Seifert JA, Scheel-Toellner D, Singaraju A, Slowikowski K, Smith M, Tabechian D, Utz PJ, Weinand K, Weisenfeld D, Weisman MH, Xiao Q, Zhu Z, Li ZJ, Cordle A, Wyse A, Wei K, Raychaudhuri S, Lynch L, Moody DB, Brenner MB, Accelerating Medicines Partnership RASLEN

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After being absorbed by HCC cells, the Cu 2+ and disulfide bond ( SS) in MONs@MOF-199 nanoparticles react with GSH in a redox reaction, and the nanostructure collapses, releasing DOX and SOR to exude their anti-tumor effects