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Dihexa stimulates neurogenesisthe growth of new neuronsand increases brain-derived neurotrophic factor Brain-Derived Neurotrophic Factor (BDNF), a protein vital for neuron survival and growth

Induction of the root cell plasma membrane ferric reductase (an exclusive role for Fe and Cu)

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It is postulated that the apoE isoform-specific effect on apoE receptor-2 and NMDA/AMPA receptor trafficking contributes to AD pathogenesis by impairing synaptic activity

PMID 34877934

The researchers on this paper speculated that thymoquinone, or TQ, the primary active constituent of [BSO], may have been primarily responsible for the effect because TQ protects cells against oxidative damage induced by a variety of free radical-generating pathologies, and it also stimulates the production of acetylcholine, which causes the release of melanin and darkening of the skin through stimulation of cholinergic receptors