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Furthermore, melatonin inhibits the activation of nuclear factor kappa B (NF-B) as a key transcription factor that mediates the inflammatory response [81]

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In addition, calcium D-pantetheine-S-sulphonate (PaSSO 3 Ca) causes an inhibition of melanogenic enzymes possibly through the alteration of tyrosinase and TRP-1 glycosylation without affecting their expression 22