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In some people, particularly older adults or those with limited protein intake, both glycine and cysteine availability may constrain glutathione synthesis

Thus, we reasoned that Gclc expression and GSH are needed upon activation of FoB

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The presence of high serum bicarbonate could indicate chronic respiratory acidosis [typical of chronic obstructive pulmonary disease (COPD)] or metabolic alkalosis (secondary to vomiting, use of thiazide diuretics, or excess mineralocorticoids) (336)

3), which promotes ferroptosis and increases sensitivity to chemotherapy ( e.g

Ultimately, integrating dynamic biomarkers, multi-omics, and artificial intelligence to tailor treatments to individual patient profiles holds the key to finally fulfilling the promise of effectively managing MIRI