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3 highlights the significant inhibition of glutamine reductive metabolism, which suggested by the lower fractions of m + 5 citrate (Fig

Methods: Gene expression was analyzed using RNA sequencing (RNA-seq), single-cell RNA sequencing (scRNA-seq), and 10x spatial transcriptomics in primary human hepatic stellate cells (hHSCs) and a CCl4-liver fibrosis induced murine model

this enables translated NRF2 to be translocated to the nucleus and stimulate transcription of genes with antioxidant response elements (AREs) (87, 88)

For deeper inflammatory patterns, the more meaningful shifts tend to show up between weeks four and eight: less bloating, fewer flare-ups, better energy, calmer skin

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