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Conversely, when PTS function is blocked via deletion of the HPr phosphocarrier protein ( ptsH ), PrfA-dependent virulence gene expression is significantly increased in vitro [20,32,54,55]

doi:10.1053/j.ajkd.2016.10.037 10 Li G, Zhou CL, Ba YM, et al

10.1007/s00253-004-1762-8

Similarly, vitamin C was shown to reduce microglial activation in a rat model of ethanol induced neuroinflammation (Takahashi et al., 2019)

Utilizing HIF-1 inhibitors, such as Roxadustat, has been shown to block IEC death, maintain intestinal barrier function, and ameliorate arthritic symptoms (143, 144)