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In addition to phosphorylation at S693, GSK3 also phosphorylates S40 and S44 sites in neuronal cells, this can drive increased GTPase activity and increase fragmentation of the mitochondria, this is also driven by phospho-mimetic mutants at S40 and S44 (Yan et al., 2015)

10.1016/j.intimp.2017.05.022 Int

Note: BPC-157 and TB-500 (T4) products are intended for research purposes only and are not approved for human therapeutic use unless authorized by applicable regulatory authorities.

The alternative NF-kappaB pathway from biochemistry to biology: pitfalls and promises for future drug development

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Immunity 41:10521063 Wieckowski M, Giorgi C, Lebiedzinska M, Duszynski J, Pinton P (2009) Isolation of mitochondria-associated membranes and mitochondria from animal tissues and cells