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Enhancements of caspase-3 and poly-(ADP-ribose) polymerase PARP levels and a reduction in the level of the Bcl2 protein in brain and liver tissues have been reported following exposure to D-galactose [5, 6, 40]

Such damage can be further exacerbated by neutrophil activation at the injury site

The most effective way to increase glutathione levels is with a liposomal product

Figure 1 3 Typing and diagnosis of diabetic cardiomyopathy and its pathogenesis 3.1 Typing and diagnostic criteria of diabetic cardiomyopathy The histological features of DCM include myocardial collagen deposition, myocardial hypertrophy, and fibrosis ( The minimum diagnostic criteria for DCM include LV diastolic dysfunction and/or reduced LV ejection fraction (LVEF), LV hypertrophy, and interstitial fibrosis and can be divided into three stages: early, advanced, and end

Cystine enters cells through the cystine/glutamate reverse transporter (system Xc ) and is then reduced via the glutathione or thioredoxin reductase 1-dependent cysteine reduction pathway to generate cysteine and promote GSH synthesis

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