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Observational data regarding embryofetal risks of NSAID use during the first trimester is inconclusive

But this is only one of the many facets of botulinum toxin use

Metabolic analysis suggests that functional deficiency in either folate or vitamin B2 is the cause of paradoxical B12 deficiency Resolution of Paradoxical deficiency requires complete resolution of the folate or functional B2 deficiency

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In addition, evidence from European trials indicates a role for intravenous immunoglobulin in reducing relapses