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(1) Adolescence (1218 years): high sensitivity to high-sugar diets Although human studies investigating the gut microbiome in adolescents remain limited, the ongoing development of the gut-brain axis and the adolescent brain suggests that this population may be particularly susceptible to diet-induced depressive symptoms (320), The impact of high-sugar diets on metabolic and intestinal health In male C57BL/6J mice, consumption of a high-glucose diet (HGD) over a 12-week period induces hyperglycemia, glucose intolerance, dyslipidemia, and increased adipose deposition

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doi: 10.1159/000489654 131 NsaibaMJLapointeMMabroukHDoukiWGahaLPrusseLet al

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Type-I IFN: Type-I IFN facilitates dendritic cell (DC) maturation, enhances autoimmune T cell survival, and activates autoantibody-producing B cells, primarily through sustained IFN- production, autophosphorylation, and activation of the IFN- receptor (IFNAR)-associated Janus kinases (JAKs) and signal transducers and activators of transcription (STATs) (87, 88)